84-1470-49　［取扱停止］ROR2, CT (Tyrosine-protein Kinase Transmembrane Receptor ROR2, Neurotrophic Tyrosine Kinase, Receptor-related 2, NTRKR2) (AP) 200ul　R2999-61C-AP

特徴

• ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes.
• It seems to be required for cartilage and growth plate development.
• This Type I membrane protein is expressed at high levels during early embryonic development.
• The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
• Defects in ROR2 are a cause of brachydactyly type B1 (BDB1).
• BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails.
• In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent.
• Both fingers and toes are affected.
• The thumbs and big toes are usually deformed.
• Defects in ROR2 are a cause of recessive Robinow syndrome (RRS).
• RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance.
• The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
• Applications:Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:500Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.