Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
MMP17 is considered a member of the membrane-type MMP (MT-MMP) subfamily.
However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein.
The protein activates MMP-2 by cleavage.
Applications:Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1,000Western Blot: 1:50-1:200Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity.
Light sensitive.
Aliquots are stable for at least 6 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A/G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phophatase.
Specificity：Recognizes human MMP17.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 391-420 in the central region of human MMP17, UniProt Accession #NP_057239; Q9ULZ9; Q9R0S3. Species Sequence Homology: mouse
