The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs).
PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes.
This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif.
Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane.
Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth.
Two alternatively spliced variants exist.
PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver.
Its expression in colorectal cancers may contribute to the establishment of liver metastasis.
In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:1,000 Western Blot: 1:100-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity.
Light sensitive.
Aliquots are stable for at least 6 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A/G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phosphatase.
Specificity：Recognizes human PRL3. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Recombinant protein encoding full length of human PRL3 (NP_116000; Q75365).
