84-1410-80　NMDA Receptor NR2B (N-methyl D-aspartate Receptor Subtype 2B, NMDAR2B, NR2B, Glutamate [NMDA] Receptor Subunit epsilon-2, Grin2b) 10ug　136938

特徴

• The ion channels activated by glutamate are divided into two classes.
• Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR).
• NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning.
• NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death.
• NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.
• Applications:Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 10ug/mlImmunohistochemistry: ParaffinImmunoprecipitation: can be used to quantitatively immunoprecipitate the NMDAR2B where 3ul will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2B in 200mg of rat brainOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.