84-1410-79　NMDA Receptor NR1, Splice Variant N1 (N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1, NMDAR1, Nmdar, NR1, Glutamate [NMDA] Receptor Subunit zeta-1, Grin1, GluRdelta1, GluRzeta1, Glurz1, M100174, Rgsc174) 25ug　136937

特徴

• N-methyl-D-aspartate receptor (NMDAR) forms a heterodimer of at least one NR1 and one NR2A-D subunit.
• Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits.
• NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.
• NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning.
• NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death.
• NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.
• Applications:Suitable for use in Immunohistochemistry and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:1000Western Blot: 1:1000-1:2000, ~100kD band in rat hippocampal homogenateOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C after receipt.
• Reconstitute with sterile PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.