Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family.
The proteins in this family are the most distantly known relatives of the well studied Hsp70 family.
They share 30-33% aa identity, mostly in the conserved ATP-binding domain (1).
Hsp110 cooperates with Hsp70 in protein folding in the eukaryotic cytosol (2).
In mammals, Hsp110 is constitutively expressed, but exhibits particularly high levels in the brain.
Both Hsp70 and Hsp110 are elevated after cerebral ischemia.
Recent studies demonstrate that the protective effects of Hsp110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70 (3).
Studies also suggest that Hsp110 can be used in heat shock protein-based cancer immunotherapy (4).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：25ug
Host：rabbit
Source Antibody：hamster
Grade：Affinity Purified
Purity：Affinity Purified.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes hamster Hsp 110 at ~110kD. Species Crossreactivity: Human, monkey, rat, mouse, bovine, sheep and yeast.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Bo Hu Mk Mo Rt Sh Ye
Immunogen：Synthetic peptide corresponding to hamster Hsp110. Species Sequence Homology: human and mouse, 100%.
