TRPM8 is a receptor activated non-selective cation channel, permeable for monovalent cations sodium, potassium, cesium and the divalent cation calcium.
It was originally identified due to its up regulation in prostate carcinoma.
It has since been shown to be involved in the detection of coldness and is activated by icilin, eucalyptol, menthol, cold, and modulation of intracellular pH.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human TRPM8. Species sequence homology: Gorilla, gibbon, baboon, monkey, marmoset, bat, canine, hamster, elephant, panda, rabbit, opossum, guinea pig, platypus; 100%, galago, mouse, rat, equine, pig, armadillo; 94%, bovine and lizard; 88%, xenopus; 82%.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 17aa from human TRPM8 at N-Terminal.
