This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family.
The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum.
The protein may function as a proprotein convertase.
This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:200Immunohistochemistry: 5ug/mlImmunocytochemistry (Paraffin): 5-8ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in TBS pH 7.4, 0.5mg/ml BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes mouse PCSK9. Species Crossreactivity: Human, rat.
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa152-163 from mouse PCSK9(VFAQSIPWNLER).
