84-1409-42　NMDAR1 (GRIN1, Glutamate [NMDA] Receptor Subunit zeta-1, N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1) 50ug　136292

特徴

• Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
• The ion channels activated by glutamate are typically divided into two classes.
• Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR).
• The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's disease, epilepsy and ischemic neuronal cell death.
• Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:20,000 Western Blot: 1:500-1:1000Immunohistochemistry (Paraffin): 10ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.