Hepcidin, an human antimicrobial peptide, contains a leader sequence, a proteolysis site and a C-terminal 25 amino acid active peptide.
This peptide is most active against gram-positive bacteria, but also inhibits the growth of certain yeast and gram-negative bacteria.
HAMP also functions as a signaling molecule involved in the maintenance of iron homeostasis.
In conjugation with HFE it seems to regulate both intestinal iron absorption and iron storage in macrophages.
Mutations in HAMP are found in juvenile hemochromatosis.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Immunohistochemistry (Paraffin): 3.75ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human HAMP/Hepcidin. Species sequence homology: Chimpanzee, gorilla, orangutan, gibbon, monkey (100%), marmoset and panda (80%).
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to TSGSVFPQQTGQLAE-C from human HAMP/Hepcidin at N-Teminal.
