The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzesproduction of lysophosphatidic acid (LPA) in extracellular fluids.
LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis.
This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas.
The gene product is secreted and further processed to make the biologically active form.
Several alternatively spliced transcript variants encoding different isoforms have been identified.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 5ug/mlImmunohistochemistry (Paraffin): 2.5ug/mlImmunocytochemistry: 2ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid TBS, pH 7.4, 0.5mg/ml BSA, 0.02% sodium azide.
Specificity：Recognizes rat ENPP2. Species Crossreactivity: Human, mouse.
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa573-588 from rat ENPP2 (KNKLEELNKRLHTKGS).
