DUSP8 encodes a dual specificity MAP kinase phosphatase which has been shown to hydrolyze p-nitrophenylphosphate and inactivate mitogen-activated protein kinases in vitro.
The mouse homologue, M3/6, has been demonstrated to be uniquely specific for JNK and p38 kinases.
DUSP8 has been mapped to 11p15, a chromosomal region that has been implicated in the development of a number of tumor types, including lung which is a tissue known to express this gene, and loss of heterozygosity has been found in one of eight informative lung tumors studied.
The presence of a CG-rich trinucleotide repeat in the coding region has been suggested to be a possible target for mutation which might result in loss of function or altered properties.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000Western Blot: 1:100-1:500Immunohistochemistry (Paraffin): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human DUSP8.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human DUSP8 at C-Terminal conjugated to KLH.
