CXCR3, a Chemokine Receptor, is highly similar to the interleukine 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS.
CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes.
It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000).
An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al.
2003).
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:5000Western Blot: 1:500-1:000Immunohistochemistry (Paraffin): 10ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human CXCR3.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human CXCR3.
