The Alpha 2a- Adrenergic Receptor functions as a post-synaptic receptor that mediates the effects of epinephrine and norepinephrine.
This adrenoceptor also functions as a presynaptic autoreceptor, inhibiting the subsequent release of neurotransmitter, especially epinephrine, from sympathetic nerves and from adrenergic neurons in the central nervous system.
Adrenergic Alpha-2A Receptor polymorphisms have been identified in individuals with Tourette's syndrome.
Furthermore, increased levels of plasma norepinephrine have been noted in children with attention-deficit hyperactivity disorder and learning disabilities.
Mutant mice lacking both Alpha 2a and Alpha 2c Receptors exhibited increased plasma noradrenaline and developed cardiac hypertrophy by four months of age.
Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:100-1:500ELISA: 1:20,000Western Blot: 1:500-1:1000 Immunohistochemistry (Paraffin): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography
Form：Supplied as a liquid in PBS, (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human ADA2A. Species Crossreactivity: Mouse, rat.
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human ADRA2A at C-Terminal.
