84-1408-14　［取扱停止］ABCA1 (ATP-binding Cassette Sub-family A Member 1, ATP-binding Cassette Transporter 1, ABC-1, ATP-binding Cassette 1, ABC1, CERP) 50ul　135871

特徴

• ABCA1 (ATP-binding Cassette, Sub-family A, Member 1), also known as ABC1 (ABC Transporter 1) or CERP (Cholesterol efflux regulatory protein), is a member of the family of ATP-binding cassette (ABC) transporters.
• It is a cAMP-dependent, sulfonylurea-sensitive traffic ATPase, which is located at the plasma membrane and plays a key role in the cellular lipid removal pathway.
• ABCA1 supports apolipoprotein A-I (APOA1)-mediated cellular efflux of cholesterol and choline-phospholipids into the blood circulation; therefore, ABCA1 defects result in reduced plasma level of high density lipoproteins (HDL) combined with the tissue deposition of cholesteryl esters.
• Homozygous mutations in ABCA1 are the cause of Tangier disease, which is characterized by the absence of HDL in plasma, hepatosplenomegaly, peripheral neuropathy, and frequently premature coronary artery disease.
• Noticeably, heterozygous Tangier disease carriers have an approximately 2-fold reduction in HDL level.
• More commonly, ABCA1 inherited defects are associated with a milder condition, so-called familial hypoalphalipoproteinemia (FHA).
• FHA patients, similar to Tangier disease patients, demonstrate a very evident decrease of HDL level; however, they lack clinical manifestations.
• Applications:Suitable for use in Western Blot, and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:5000 Immunohistochemistry (Paraffin): 1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.