Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily.
They activate mitogenic responses and regulate growth and proliferation of many cells.
There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation.
This protein encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines.
Thus, this normal cellular gene is identified as a protooncogene.
This protein comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.
Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276~306 amino acids from the Central region of human ADRA1B.
