Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes.
The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity.
Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development.
Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.
Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human, Hamster
Isotype：IgG
Calc Applications Abbrev：E FC IHC WB
Calc Crossreactivity：Hm Hu
Immunogen：DAAM1-T361 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-378 amino acids from the N-terminal region of human DAAM1-T361.
