This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.
The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach.
Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.
This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Applications:Suitable for use in Immunofluorescence, Dot Blot and ELISA.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:200Dot blot: 1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human Sox2.
Isotype：IgG
Calc Applications Abbrev：DB E IF
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic phospho-peptide mapping to a fragment of residues surrounding S246 of human Sox2, UniProt Accession #P48431. Species sequence homology: mouse
