MUC1 is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein.
The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type.
It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals.
The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.
Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.
Applications:Suitable for use in Immunofluorescence, Dot Blot, ELISA
Recommended Dilution:ELISA: 1:1,000Dot blot 1:500Immunofluorescence: 1:10-50
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：DB E IF
Calc Crossreactivity：Hu
Immunogen：Phospho-MUC1-Pt1224 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 1210-1240 surrounding T1224 of human MUC1.
