The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription.
The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription.
Applications:Suitable for use in Immunofluorescence, Dot Blot, ELISA
Recommended Dilution:ELISA: 1:1,000Dot Blot 1:500Immunofluorescence: 1:10-50
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：DB E IF
Calc Crossreactivity：Hu
Immunogen：Phospho-CDX2-S283 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 268~297 amino acids surrounding S283 of human CDX2.
