Kr¸ppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon.
It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene.
KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells.
KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.
Applications:Suitable for use in Immunofluorescence, Dot Blot, ELISA
Recommended Dilution:ELISA: 1:1,000Dot Blot 1:50-100
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：DB E IF
Calc Crossreactivity：Hu
Immunogen：Phospho-KLF4-S245 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 132~161 amino acids surrounding S245 of human KLF4.
