84-1312-59　ErbB2, phosphorylated (Y1248) (Receptor tyrosine-protein kinase erbB-2 [Precursor], p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, ERBB2, HER2, NEU, NGL) 200ul　035187

特徴

• ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
• This protein has no ligand binding domain of its own and therefore cannot bind growth factors.
• However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
• Amplification and/or overexpression of the ErbB2 gene has been reported in numerous cancers, including breast and ovarian tumors.
• Applications:Suitable for use in Dot Blot, ELISA
• Recommended Dilution:ELISA: 1:1,000Dot Blot 1:500
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.