Kr¸ppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon.
It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene.
KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells.
KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.
Applications:Suitable for use in Western Blot, Immunofluorescence and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Immunofluorescence: 1:10-1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human KLF4.
Isotype：IgG
Calc Applications Abbrev：E IF WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 481-504 of human KLF4, UniProt Accession #O43474; Q9Y5W3. Species sequence homology: mouse, rat
