84-1310-46　KRT86, ID (KRT86, KRTHB6, Keratin, type II cuticular Hb6, Hair keratin K2.11, Keratin-86, Type II hair keratin Hb6, Type-II keratin Kb26) 200ul　037636

特徴

• The protein encoded by this gene is a member of the keratin gene family.
• As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails.
• The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity.
• One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related.
• The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.
• All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex.
• Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.
• Applications:Suitable for use in Western Blot and ELISA Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.