84-1310-19　BMPR2, NT (Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, PPH1) 200ul　032551

特徴

• BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases.
• The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily.
• BMPs are involved in endochondral bone formation and embryogenesis.
• These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD.
• Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
• Mutations in BMPR2 have been associated with primary pulmonary hypertension.
• Applications:Suitable for use in Immunohistochemistry, Indirect Flow Cytometry and ELISA.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry (FFPE): 1:50-1:100Indirect Flow Cytometry: 1:10-1:50Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.