Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals.
mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive.
mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.
mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation.
mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'.
mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling.
May act as a tumor suppressor in breast cancer (By similarity).
Applications:Suitable for use in Western Blot, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Mo
Immunogen：Mouse Prr5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of mouse Prr5.
