Xaf1 seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family.
Inhibits anti-caspase activity of BIRC4.
Induces cleavage and inactivation of BIRC4 independent of caspase activation.
Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells.
May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway.
After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria.
Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm.
The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4.
Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL.
May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).
Applications:Suitable for use in Western Blot, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Mo
Immunogen：Mouse Xaf1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of mouse Xaf1.
