This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five.
These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.
The gamma gene cluster includes 22 genes divided into 3 subfamilies.
Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes.
The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster.
Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region.
The constant region exons encode the common cytoplasmic region.
These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain.
This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury.
Alternative splicing has been described for the gamma cluster genes.
Applications:Suitable for use in Western Blot, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：PCDHGB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 352-379 amino acids selected from the Central region of human PCDHGB4.
