This gene is a member of the CLC family of voltage-gated chloride channels.
The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel.
It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear.
The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene.
Multiple transcript variants encoding different isoforms have been found for this gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human CLCNKA at ~75kD.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa20-47 in the N-terminal region of human CLCNKA, UniProt Accession #P51800; NP_001036169.1; NP_004061.3 Cellular Location: Membrane; Multi-pass membrane protein. Tissue Location: Expressed predominantly in kidney.
