KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism.
Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation.
May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4.
In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation.
May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity).
Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
Applications:Suitable for use in Western Blot, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：KIDINS220 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1517-1547 amino acids from the C-terminal region of human KIDINS220.
