Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis.
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity).
Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis.
Required for kinetochore localization of BUB1 and SGOL1 (By similarity).
Applications:Suitable for use in Western Blot, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Mouse Aurkb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the N-terminal region of human Mouse Aurkb.
