84-1275-91　LIN28B, CT (LIN28B, CSDD2, Protein lin-28 homolog B) 200ul　037797

特徴

• Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma.
• The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans.
• Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains.
• Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene.
• Overexpression of LIN28B was noted in most HCC cell lines and clinical samples.
• A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver.
• Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells.
• Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.
• Applications:Suitable for use in Western Blot, Indirect Flow Cytometry, ELISA
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:50-100Indirect Flow Cytometry: 1:10-50
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.