CDH4 is a classical cadherin from the cadherin superfamily.
It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail.
Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth.
In addition, a role in kidney and muscle development is indicated.
Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines.
Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Indirect Flow Cytometry and ELISA.
Other applications have not been tested.
Recommended Dilution:Western Blot: 1:1000Immunohistochemistry: 1:10-1:50Immunofluorescence 1:10-1:50Indirect Flow Cytometry: 1:10-1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human CDH4.
Isotype：IgG
Calc Applications Abbrev：E FC IF IHC WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 175-203 in the N-terminal region of human CDH4, UniProt Accession #P55283. Species sequence homology: mouse, rat
