Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division.
The cohesin multiprotein complex is required for sister chromatid cohesion.
This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene.
Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain.
Therefore, the encoded protein is thought to be an important part of functional kinetochores.
In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair.
This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
[provided by RefSeq].
Applications:Suitable for use in Western Blot, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-336 amino acids from the N-terminal region of human SMC1A.
