RBL2 is a key regulator of entry into cell division.
Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.
Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression.
Controls histone H4 'Lys-20' trimethylation.
Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5.
Binds to cyclins A and E.
Binds to and may be involved in the transforming capacity of the adenovirus E1A protein.
RBL2 may act as a tumor suppressor.
Applications:Suitable for use in Western Blot, Indirect Flow Cytometry, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E FC WB
Calc Crossreactivity：Hu
Immunogen：RBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-195 amino acids from the N-terminal region of human RBL2.
