GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity.
Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity.
It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.
Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt.
It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system.
It seems to be oncogenic.
It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Applications:Suitable for use in Western Blot, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human, mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1.
