CREBBP is an acetyltransferase enzyme that acetylates histones, giving a specific tag for transcriptional activation.
It also acetylates non-histone proteins, like NCOA3 coactivator.
This protein mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.
CBP, as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes.
Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias.
For example, MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
Defects in CREBBP are also the cause of Rubinstein-Taybi syndrome (RSTS).
RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Applications:Suitable for use in ELISA
Recommended Dilution:ELISA: 1:1,000
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：CREBBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169~199 amino acids from the N-terminal region of human CREBBP.
