84-1241-95　WDR48, CT (WDR48, KIAA1449, UAF1, WD repeat-containing protein 48, USP1-associated factor 1, WD repeat endosomal protein, p80) 200ul　043838

特徴

• Regulator of deubiquitinating complexes.
• Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself.
• Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively.
• Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate.
• In case of infection by Herpes virus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.
• Induces lysosomal vesicle formation via interaction with Herpes virus saimiri tyrosine kinase-interacting protein (TIP).
• Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR.
• May play a role in generation of enlarged endosomal vesicles via interaction with TIP.
• In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry, ELISA
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:100-500Immunohistochemistry: 1:50-100Indirect Flow Cytometry: 1:10-50
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.