This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).
This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL.
This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues.
It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.
The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb.
The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.
The coding region is not affected by alternative splicing.
[provided by RefSeq].
Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Human, mouse
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：MME antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 728-755 amino acids from the Central region of human MME.
