84-1239-21　Peripherin (Prph, Prph1) 100ul　031421

特徴

• Peripherin is a ~57kD intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name (1).
• The HGNC name for this protein is PRPH.
• Subsequently peripherin was found in some sensory and other neurons of the central nervous system and also in rat pheochromacytoma PC12 cells (2,3).
• Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas.
• Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin.
• Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system.
• Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors.
• Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes.
• Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.
• The HGNC name for this protein is PRPH.
• Applications:Suitable for use in Immunocytochemistry and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunocytochemistry: For cells in tissue culture or in tissue sections, try this antibody at about between about 1:1000 using fluorescent secondary antibodies or 1:5000 using peroxidase or other enzyme linked methods
• Western Blot: 1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.