PR domain proteins (PRDMs) have been associated with many types of human cancers.
PRDM14 was found to be up-regulated in breast cancer cells.
The expression of PRDM14 to breast cancer cells actually increased cell proliferation and decreased the effect of chemotherapeutic drugs, while down-regulation of PRDM14 did the opposite.
In addition to breast cancer, PRDM14 has recently been linked to non-small cell lung cancer development.
PRDM14 also seems to play a role in the preservation of the self-renewal of human embryonic stem cells and transcriptional regulation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000 detected PRDM14 in 10ug of human lung tissue lysate
Optimal dilutions to be determined by the researcher.
Positive Control:Human lung tissue lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Specificity：Recognizes human PRDM14. Species Crossreactivity: Mouse and rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to the N-terminus of human PRDM14, fused to GST-Tag.
