84-1238-74　［取扱停止］PDE4D3, NT (cAMP-specific 3',5'-cyclic Phosphodiesterase 4D, DPDE3, PDE43) 100ug　029577

特徴

• Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides.
• PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells.
• PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation.
• PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle.
• Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects.
• PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Mouse brain membrane tissue lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.