Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains.
Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription.
Plays a role in the regulation of cell morphology and cytoskeletal organization.
Required in the stress fiber dynamics and cell migration.
May also modulate TNF-alpha signaling.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilutions:ELISA (Peptide): 1:4000Western Blot: 1-3ug/ml,using human brain (cerebellum) lysates.
Band at ~80kD
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Specificity：Recognizes human ZRANB1
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to KWLDRYRQIRPCTS from the C-terminal of human ZRANB1. Species Sequence Homology: bovine, canine, mouse, porcine and rat
