Van Gogh is an alternate name for the Drosophila strabismus protein.
Van Gogh like-2 (VANGL2) is a 521aa protein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-dishevelled tissue polarity pathway.
It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor.
It is predominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate.
It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea.
VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process.
It is expressed in a wide range of tissues.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.3-1ug/ml, observed in human lung and mouse brain lysates on ~55kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human VANGL2. Species Crossreactivity: Mouse. Species sequence homology: Bovine and zebrafish.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Bo Hu Mo Ze
Immunogen：Synthetic peptide corresponding to C-QKYLRTTKQQPYH, from VANGL2, at the internal region of the protein (NP_065068.1).
