May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A).
Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro.
The PP2A(C):TIPRL complex does not show phosphatase activity.
May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:16,000Western Blot: 1-3ug/ml, lysates of cell line K562 observed on ~30kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human TIPRL. Species sequence homology: Bovine, canine, mouse and rat.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Bo Ca Hu Mo Rt
Immunogen：Synthetic peptide corresponding to C-RIDPNPADSQKSTQ, from human TIPRL, at C-terminal (NP_690866.1).
