SH2D1A is an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association.
This protein is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver.
Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD) also known as Duncan disease.
XLPD is characterized by a rare congenital immunodeficiency following Epstein-Barr virus (EBV) infection.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.2-0.6ug/ml, observed in human lymph node lysates on ~16kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human SH2D1A. Species sequence homology: Porcine.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Po
Immunogen：Synthetic peptide corresponding to C-QYPVEKKSSARSTQ, from human SH2D1A, at the internal region of the protein (NP_002342.1, NP_001108409.1).
