84-1230-95 SNX9 (Sorting Nexin-9, SH3 and PX Domain-containing Protein 1, Protein SDP1, SH3 and PX Domain-containing Protein 3A, SH3PX1, SH3PXD3A) 100ug S1013-31E8
84-1230-95 SNX9 (Sorting Nexin-9, SH3 and PX Domain-containing Protein 1, Protein SDP1, SH3 and PX Domain-containing Protein 3A, SH3PX1, SH3PXD3A) 100ug S1013-31E8
May be involved in several stages of intracellular trafficking.
Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis.
Plays a role in macropinocytosis.
Promotes internalization of TNFR.
Promotes degradation of EGFR after EGF signaling.
Stimulates the GTPase activity of DNM1.
Promotes DNM1 oligomerization.
Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton.
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation.
Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000Western Blot: 0.1-0.3ug/ml, observed in human heart and placenta lysates on ~60kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human SNX9. Species sequence homology: Canine and mouse.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Ca Hu Mo
Immunogen：Synthetic peptide corresponding to C-HKGAIEKVKESDK, from human SNX9, at the internal region of the protein (NP_057308.1).
