Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.
They have a role in regulating cell growth and differentiation in specific cell types.
SFRP4 may act as a regulator of adult uterine morphology and function.
Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling.
Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
Applications:Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA (Peptide): 1:32,000Western Blot: 1-3ug/ml detects a band at ~40kD in human uterus lysatesImmunohistochemistry (Paraffin): 2-4ug/ml using paraffin embedded human uterus shows grandular staining in the apical cytoplasm of the endometrial glandOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human SFRP4.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa TNSSCQCPHILPHQD, from an internal region of human SFRP4 (NP_003005.2). Species sequence homology: bovine, mouse, porcine and rat.
