PTP mu, a R2A receptor is a member of the protein tyrosine phosphatase (PTP) family.
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP.
The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats.
This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell.
This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.
The Human PTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in Human cancer.
PTP mu may be important in responses to pathological conditions associated with the loss of cell-cell interactions in the heart.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:16,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes PTPRM. Species sequence homology: Canine, human and mouse.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Ca Hu Mo
Immunogen：Synthetic peptide corresponding to C-KLIRQVDKWQEEYN, from PTPRM, at the internal region of the protein (NP_001098714.1, NP_002836.3).
