PRDM16, also known as Mel1, is a zinc finger protein that plays a role in the differentiation of brown adipose tissue, which plays a role in dissipating heat in response to cold or excess feeding.
PRDM16 works together with CEBPB to regulate the differentiation of myoblastic precursors into brown adipose cells.
PRDM16 is also a repressor of TGF beta signalling, interacting with SKI to promote the recruitment of the SMAD3-HDAC1 complex to the promoter of TGF beta target genes.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes PRDM16. Species sequence homology: Human.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-TSESGAFHPINHL, from PRDM16, at C-terminal (NP_071397.2, NP_955533.1).
